Todo lo que sigue trata de Selank. Mantenemos un lenguaje claro, nos apoyamos en la literatura y separamos lo bien documentado de lo que sigue abierto.
Actualizado el 2025-12-26. Las cifras y descripciones siguen la literatura publicada, no el material promocional.
Pinto, J.M., Montagna, J.M., Vecchietti, A.R., Iribarren, O.A. and Asenjo, J.A. (2001) Process performance models in the optimization of multiproduct protein production plants. Biotechnol. Bioeng., 74, 451-465. 131. Salazar, O., Molitor, J., Lienqueo, M.E. and Asenjo, J.A. (2001) Overproduction, purification and characterization of -1,3-glucanase type II in Escherichia coli. Protein Express. and Purif., 23, 219-225. 132. Graber, T.A., Galleguillos, H., Asenjo, J.A. and Andrews, B.A. (2002) Refractive Index, Density, and Viscosity in the NaNO3 + H2O + Poly(ethylene glycol) System at various Temperatures. J. Chem. Eng. Data, 47, 174 – 178. 133. Asenjo, J.A., Mistry, S.L., Andrews, B.A. and Merchuk, J.C. (2002) Phase separation rates of aqueous two-phase systems: correlation with system properties. Biotechnol. Bioeng.79, 217-223. 134. González, R., Andrews, B.A. and Asenjo, J.A. (2002) Kinetic model for BiP- and PDI- mediated protein folding and assembly. J. Theor. Biol., 214, 529-537. 135. Salamanca, M.H., Barria, C., Asenjo, J.A. and Andrews, B.A. (2002) Isolation, purification and preliminary characterization of cryophilic proteases of marine origin. Bioseparation. 10, 237 – 241. 136. Berggren, K., Wolf, A., Asenjo, J.A., Andrews, B.A. and Tjerneld, F. (2002) The surface exposed amino acid residues of monomeric proteins determine the partitioning in aqueous two-phase systems. Biochim. Biophys. Acta. 1596, 253-268. 137. Lienqueo, M.E., Mahn A. and Asenjo J.A. (2002) Mathematical correlations for predicting protein retention times in hydrophobic interaction chromatography.
Fuentes: es.wikipedia.org
J. Chromatography A, 978, 71-79. 138. González, R., Andrews, B.A., Molitor, J. and Asenjo, J.A. (2003) Metabolic analysis of the synthesis of high levels of intracellular human SOD in S. Cerevisiae rhSOD 2060 411 SGA122. Biotechnol. Bioeng. 82, 152-169. 139. Shene, C., Andrews B.A. and Asenjo J.A., (2003) Study of recombinant microorganism populations characterized by their plasmid content per cell using a segregated model. Bioprocess and Biosyst. Eng. 25, 333-340. 140. Lienqueo, M.E., Mahn A., Vásquez L. and Asenjo J.A., (2003) Methodology for predicting the separation of proteins by hydrophobic interaction chromatography and its application to a cell extract. J. Chromatography A, 1009, 189 -196. 141. Olivera-Nappa, A, Andrews, B.A. and Asenjo J.A., (2004) A mixed mechanistic-electrostatic model to explain pH dependence of glycosyl hydrolase enzyme activity. Biotechnol.Bioeng., 86, 573 – 586. 142. Asenjo, J.A. and Andrews, B.A. (2004) Is there a Rational Method to Purify Proteins? : From Expert Systems to Proteomics. J.of Molecular Recognition, 17, 236-247. 143. Iribarren, O.A., Montagna, J.M., Vecchietti, A.R., Andrews, B.A., Asenjo J.A., and Pinto J.M. (2004) Optimal Process Synthesis for the Production of Multiple Recombinant Proteins. Biotechnology Progress 20 , 1032 – 1042. 144. Mahn, A., Lienqueo, M.E. and Asenjo, J.A. (2004) Effect of Surface Hydrophobicity Distribution on Protein Retention in Hydrophobic Interaction Chromatography. J. of Chromatography A, 1043, 47-55. 145. Olivera-Nappa, A., Lagomarsino, G., Andrews, B.A.
Fuentes: es.wikipedia.org
and Asenjo, J.A., (2004) Effect of Electrostatic Energy on Partitioning of Proteins in Aqueous Two-Phase Systems, J. of Chromatography B, 807, 81-86. 146. Andrews, B.A., Schmidt, A.S. and Asenjo, J.A., (2005) Correlation for the Partition Behaviour of Proteins in Aqueous Two Phase Systems: Effect of Surface Hydrophobicity and Charge. Biotechnol. Bioeng. 90, 380 – 390. 147. Mahn, A., Zapata, G. and Asenjo, J.A., (2005) A theory of protein-resin interaction in hydrophobic interaction chromatography, J. of Chromatography A, 1066, 81-88. 148. Salgado, C., Rapaport, I. and Asenjo, J.A., (2005) Is it possible to predict the average surface hydrophobicity of a protein using only its amino acid composition? J. of Chromatography A, 1075, 133-143. 149. Mahn, A. and Asenjo, J.A., (2005) Prediction of protein retention in hydrophobic interaction chromatography. Biotechnology Advances 23, 359 - 368. 150. Salgado, C., Rapaport, I. and Asenjo, J.A (2005) Prediction of retention times of proteins in hydrophobic interaction chromatography using only their amino acid composition. J. of Chromatography A. 1098, 44-54. 151. Ezquer, F., Núñez, M.T., Asenjo, J.A. and Israel, Y., (2006) Hereditary Hemochromatosis: an opportunity for gene therapy. Biol. Res., 39, 113-124. 152. Salgado, C., Rapaport, I. and Asenjo, J.A. (2006) Predicting the behaviour of proteins in hydrophobic interaction chromatography, 1: using the hydrophobic imbalance (HI) to describe their surface amino acid distribution J. Chromatography A., 1107, 110-119. 153. Salgado, C., Rapaport, I., and Asenjo, J.A.
Fuentes: es.wikipedia.org
(2006) Predicting the behaviour of proteins in hydrophobic interaction chromatography, 2: using a statistical description of their surface amino acid distribution, J. Chromatography A. 1107, 120-129. 154. Salazar, O., Basso, C., Barba, P., Orellana, C. and Asenjo, J.A. (2006) Improvement of the Lytic Properties of a beta-1,3-Glucanase by Directed Evolution. Molecular Biotechnology. 33, 211-220. 155. Lienqueo, M.E., Mahn, A., Navarro, G., Perez-Acle, T., Salgado, J.C., Rapaport, I., Asenjo, J.A. (2006), New approaches for predicting protein retention time in hydrophobic interaction chromatography. J. Molec. Recog. 19, 260-9. 156. Shene, C., Lucero, A., Andrews, B.A. and Asenjo, J.A (2006) Mathematical Modelling of Elution Curves for a Protein Mixture in Ion Exchange Chromatography and for the Optimal Selection of Operational Conditions. Biotechnol. Bioeng. 95, 704-713. 157. Mahn, A., Lienqueo, M.E. and Asenjo, J.A. (2007) Optimal Operation Conditions for Protein Separation in Hydrophobic Interaction Chromatography. J. of Chromatography B. 849, 236-242. 158. Lienqueo, M.E, Mahn A., Salgado, J.C. and Asenjo, J.A. (2007) Current insights on protein behaviour in hydrophobic interaction chromatography. Journal of Chromatography B. 849, 53-68. 159. Asenjo, J.A., Ramirez, P., Rapaport, I., Aracena, J., Goles, E., and Andrews, B.A. (2007) A Discrete Mathematical Model Applied to Genetic Regulation and Metabolic Networks. J. of Microbiology and Biotechnology 17, 496-510. 160. Salazar O. and Asenjo J.A. (2007), Enzymatic lysis of microbial cells. Biotechnol Lett, 29, 985 – 994. 161.
Fuentes: es.wikipedia.org
Selank se resume aquí a partir de literatura pública: definición, contexto y los puntos que se repiten en la práctica. Información general, no consejo médico.
La investigación sobre Selank se apoya sobre todo en estudios de laboratorio y en modelos animales; los datos clínicos varían según la sustancia. Reflejamos el estado de la literatura.
Lo decisivo son la pureza y la analítica (HPLC, espectrometría de masas), una reconstitución correcta y un almacenamiento adecuado.%!(EXTRA string=Selank)
No todos los mecanismos están demostrados y un estudio aislado no es evidencia global. Esta página señala las preguntas abiertas en lugar de darlas por resueltas.%!(EXTRA string=Selank)